1350 The role of mitochondria in skin aging

As the global population continues to age, aging research has become an important topic for achieving healthy and preventing age-related diseases. Aging of skin, largest organ body, is one major factors that reduce quality life in terms function appearance. Today, mitochondrial dysfunction known be hallmarks. Mitochondria are intracellular organelles primarily produce ATP. It generally accepted increased ROS production due decreases bioenergetic efficiency accelerates cellular senescence, leading aging. However, it still unclear whether have a causal role skin In this study, we aimed determine changes associated with epidermal cells effect on phenotypes vivo. First, compared young wild-type mice (3-month-old) aged (25-month-old) examine occur epidermis. Next, further confirm association between aging-related deterioration created genetically modified mice, which was decreased cells. We demonstrated DNA content significantly epidermis from mice. also found had reduced dorsal hair density delayed regrowth after depilation Mice dysfunctional mitochondria exhibited similar phenotype. These observations suggest affects follicle maintenance regeneration. Our findings indicate contributes aging, may prevent dysfunction.